53405.rar -

While its primary role often appears structural, it can insert into membranes to regulate chloride ion flow, affecting cellular volume and pH.

It associates with proteins like ezrin to stabilize complex membrane structures. 3. Physiological Significance

The importance of CLIC5 (53405) is most evident in two major systems:

Autosomal recessive nonsyndromic deafness has been linked to disruptions in this gene.