: In a healthy brain, these fragments are cleared away. In Alzheimer’s, an imbalance between protein production and clearance leads to an accumulation of Aβ42 , a particularly "sticky" form of the protein.
: These sticky fragments clump together, first forming small groups called oligomers, and eventually maturing into the large, dense deposits known as senile plaques . 2. Impact on Brain Function amyloid protein plaque
New FDA-approved blood tests for diagnosing Alzheimer's disease : In a healthy brain, these fragments are cleared away
: Enzymes called secretases (specifically β-secretase and γ-secretase) cut APP into smaller fragments. : In a healthy brain