Antitauon Info

The concept of "tauons" arises from the observation that misfolded tau protein isoforms can propagate through the brain in a characteristic pattern, similar to prions, driving the progression of conditions like Alzheimer's disease. Antitauon therapies aim to intervene in this process through several key mechanisms:

Using antibodies to bind to extracellular tau species, preventing them from being taken up by healthy neighboring neurons. antitauon

Promoting the removal of pathological tau via microglia or through intracellular degradation pathways like the proteasome. Key Therapeutic Strategies The concept of "tauons" arises from the observation

Stopping tau proteins from sticking together to form toxic seeds. Gosuranemab Active Immunotherapy

Current research focuses on both to combat these tauon species: Example Agents / Trials Passive Immunotherapy

Administration of lab-made monoclonal antibodies (mAbs) to target specific tau epitopes. , Semorinemab , Gosuranemab Active Immunotherapy