Basic Radiotherapy Physics And Biology -

: Oxygenated cells are about three times more sensitive to radiation than hypoxic (oxygen-poor) ones. As a tumor shrinks, previously hidden hypoxic areas get better blood flow and become easier to kill.

: These deposit energy sparsely. Most of their damage is indirect and easily repairable by healthy cells. Basic Radiotherapy Physics and Biology

Unlocking the Science of Healing: A Deep Dive into Basic Radiotherapy Physics and Biology : Oxygenated cells are about three times more

: These create dense "tracks" of ionization, causing complex, clustered DNA damage that is much harder for a cancer cell to survive. Further Reading Most of their damage is indirect and easily

: Normal cells are often better at repairing sublethal DNA damage than cancer cells.

: Different tissues have inherent differences in how they respond to radiation. For example, lymphocytes and bone marrow are highly sensitive, while muscle and nerve tissues are more resistant. 3. High-LET vs. Low-LET Radiation

: At the energies used in treatment, photons (X-rays) typically interact via Compton scattering , where they bounce off electrons and transfer energy to them. Direct vs. Indirect Ionization : Direct : The radiation beam itself breaks DNA strands.