2025 Lexus RX 350 Gas Mileage by Configuration. The 2025 Lexus RX mpg differs based on which trim level and powertrain you select. Temecula Valley Lexus 2026 Lexus RX 350 Specs & Features - Edmunds
Table_title: Overview Table_content: header: | Combined MPG | 24 MPG | row: | Combined MPG: Drive Type | 24 MPG: all wheel drive | buy new lexus rx 350
: The front-wheel-drive (FWD) model achieves an EPA-estimated 22 city / 29 highway MPG , while the all-wheel-drive (AWD) version is slightly lower at 21 city / 28 highway MPG . 2025 Lexus RX 350 Gas Mileage by Configuration