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Nrf2 (Nuclear factor erythroid 2-related factor 2) acts as a master regulator of antioxidant, detoxifying, and anti-inflammatory enzymes. While Nrf2 itself cannot be consumed, natural compounds like sulforaphane, curcumin, and resveratrol act as potent activators, with pharmaceutical options such as dimethyl fumarate available for specific conditions. For a detailed overview of Nrf2 activator types and their mechanisms, see the comprehensive guide at GoodRx .