Dnaddr.mica_p-1-10.1.var

The string Dnaddr.Mica_P-1-10.1.var follows a structured bioinformatic naming convention:

: Often refers to a specific database or data-processing pipeline used for variant annotation. Mica_P : Indicates the protein product (P) of the MICA gene. Dnaddr.Mica_P-1-10.1.var

: MICA antibodies are a known factor in the rejection of kidney and heart transplants. Discrepancies between the donor's and recipient's MICA variants can trigger an immune response [6]. The string Dnaddr

: Under normal conditions, MICA is rarely expressed on healthy cells. However, it becomes highly expressed when cells undergo viral infection, malignant transformation (cancer), or heat shock [2, 3]. The MICA gene encodes a cell surface glycoprotein

The MICA gene encodes a cell surface glycoprotein that acts as a "distress signal."

: MICA serves as a ligand for the NKG2D receptor , which is found on Natural Killer (NK) cells and certain T cells [1, 2].