EASL Clinical Practice Guidelines: Drug-induced liver injury

Occurs predictably when a certain toxic threshold is reached. The most common example is Paracetamol (Acetaminophen) overdose.

Drug-induced liver injury (DILI), commonly referred to in French medical literature as , involves liver inflammation triggered by exposure to medications, supplements, or herbal products. It is the leading cause of acute liver failure in Western countries and a major reason for withdrawing drugs from the market. 1. Classification and Mechanisms