The combination of lowering glucose absorption (PGX) and enhancing insulin action (sitagliptin) produces a greater reduction in hyperglycemia compared to either agent alone. 4. Discussion & Conclusion
Obese Zucker diabetic fatty (ZDF) rats (a standard model for type 2 diabetes). Groups: Control (Cellulose/Vehicle). NPS (5% wt:wt) + Vehicle. Cellulose + Sitagliptin [10 mg/(kg · d)]. NPS (5%) + Sitagliptin [10 mg/(kg · d)].
A dipeptidyl peptidase 4 (DPP4) inhibitor that increases glucagon-like peptide-1 (GLP-1) [17].
The dual approach of limiting sugar intake via satiety/viscosity and enhancing hormone response manages diabetes more effectively.
However, I can provide a (specifically, the research on using PolyGlycopleX (PGX) combined with sitagliptin, as discussed in PMC3718709 and ScienceDirect ):
To determine if combining NPS (PGX) with sitagliptin reduces hyperglycemia in Zucker diabetic fatty (ZDF) rats better than either treatment alone [17]. 2. Methodology