: Halle Berry and Stephen Merchant engage in an escalating game of extreme, self-mutilating dares.

Movie 43 is an anthology film composed of various vignettes, each directed by different filmmakers including , Elizabeth Banks , and James Gunn . The sketches are loosely tied together by a "wraparound" plot involving a desperate screenwriter (played by Dennis Quaid) pitching insane ideas to a studio executive.

The film leans heavily into "gross-out" humor, pushing social taboos to their absolute limits. Notable sketches include: