Understanding this specific 1.7 Å conformation is essential for developing "first-in-class" inhibitors (like the compound BT5 ) to treat specific pediatric leukemias driven by NSD1 malfunctions. Handling .7z Files NSD1 - an overview | ScienceDirect Topics
The 1.7 Å structure revealed a "regulatory loop" that physically blocks the protein's active site. nsd1.7z
This loop only moves to allow gene methylation when it interacts with a nucleosome , ensuring that NSD1 only works when it is properly positioned on DNA. Understanding this specific 1