Nucleoside Reverse Transcriptase Inhibitor -

The Role and Mechanism of Nucleoside Reverse Transcriptase Inhibitors (NRTIs)

Because NRTIs lack a 3'-hydroxyl group, once they are incorporated into the growing viral DNA strand, no further nucleotides can be added. This prematurely stops the conversion of viral RNA into DNA, preventing the virus from replicating. Commonly Used NRTIs nucleoside reverse transcriptase inhibitor

NRTIs function as "prodrugs," meaning they are inactive upon entry and require by host cell kinases to become active triphosphate metabolites. Once activated, their mechanism follows two critical steps: The Role and Mechanism of Nucleoside Reverse Transcriptase