: House is motivated by an unfamiliar sense of guilt. He ponders the unfairness of a "misanthropic drug addict" surviving while a promising young physician dies.
: House’s subconscious manifests a guide who prompts him to identify the patient. He eventually realizes her necklace is made of amber, signifying that the "dying patient" is actually Amber Volakis , Wilson’s girlfriend. [S4E16] House's Head (Part 2)
: The finale fundamentally alters the series' core relationship. Wilson is left alone, finding a final note from Amber, while House awakens from a coma to face the wreckage of his friendship. : House is motivated by an unfamiliar sense of guilt