Senescence

Uncovering the Signatures of Cellular Senescence ... - bioRxiv

: The overall decline in an individual's health, leading to increased death rates and decreased fertility. Senescence

Senescence is the biological process of , characterized by a gradual decline in the functional capabilities of cells and whole organisms. It acts as a double-edged sword: while it prevents the growth of damaged or cancerous cells, the long-term accumulation of these "zombie cells" drives chronic inflammation and age-related diseases. The Two Levels of Senescence Uncovering the Signatures of Cellular Senescence

Senescent cells are identified by specific physical and chemical changes: Senescence

: A state where cells permanently stop dividing but do not die, triggered by stressors like DNA damage or telomere shortening. Key Hallmarks of Senescent Cells