The transition from a self-limiting seizure to SE involves a failure of endogenous seizure-terminating mechanisms. Rapid internalization of GABAAcap G cap A cap B cap A sub cap A receptors reduces inhibitory neurotransmission.
Historically defined as 30 minutes of continuous seizure activity, the clinical definition of Status Epilepticus has shifted toward a more functional approach. The International League Against Epilepsy (ILAE) now recognizes two operational time points: Status Epilepticus: A Clinical Perspective
NMDA and AMPA receptors are trafficked to the synaptic membrane, creating a state of self-sustaining excitatory toxicity. The transition from a self-limiting seizure to SE
Airway, breathing, circulation (ABC) and blood glucose check. 2. Pathophysiology: The Failure of Termination
, when long-term consequences like neuronal death or alteration of metabolic networks are likely to occur (typically 30 minutes). 2. Pathophysiology: The Failure of Termination
, when treatment should begin (typically 5 minutes for generalized tonic-clonic seizures), and